Abstract #0054
HERITABILITY OF WHITE MATTER (WM) FIBRES BASED ON FIBRE ORIENTATION DISTRIBUTION (FOD) MEASUREMENTS ON HARDI DATA
Kaikai Shen 1 , Stephen Rose 1 , Jurgen Fripp 1 , Katie McMahon 2 , Greig de Zubicaray 3 , Nicholas Martin 4 , Paul Thompson 5 , Margaret Wright 4 , and Olivier Salvado 1
1
Australian e-Health Research Centre, CSIRO,
Herston, Queensland, Australia,
2
Centre
for Advanced Imaging, University of Queensland, St
Lucia, Queensland, Australia,
3
School
of Psychology, University of Queensland, St Lucia,
Queensland, Australia,
4
Queensland
Institute of Medical Research, Herston, Queensland,
Australia,
5
Imaging
Genetics Centre, University of Southern California, Los
Angeles, California, United States
We aim to estimate the genetic influence on WM
structures using Fibre Orientation Distrubution (FOD)
based measurements. We hypothesize that because FOD
resolves the crossing fibres, it will allow measuring
genetic influence on intra-voxel fibre structures. We
estimated the heritability of FOD measures over a twin
cohort, by projecting the heritability of FOD onto fibre
tracks, and estimating the genetic influence along fibre
tracks.
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