Abstract #0051
19F MRI for Evaluating ERK1 as a Factor Regulating Dendritic Cell Migration in High Grade Glioma
Min-Chi Ku 1 , Martin Gnther 1 , Conrad Martin 1 , Stefano Lepore 1 , Helmar Waiczies 1,2 , Andreas Pohlmann 1 , Susanne A. Wolf 3 , Helmut Kettenmann 3 , Thoralf Niendorf 1 , and Sonia Waiczies 1
1
Berlin Ultrahigh Field Facility (B.U.F.F.),
Max Delbrck Center for Molecular Medicine, Berlin,
Germany,
2
MRI.TOOLS
GmbH, Berlin, Berlin, Germany,
3
Cellular
Neurosciences, Max Delbrck Center for Molecular
Medicine, Berlin, Germany
Immunotherapy with dendritic cell based vaccines for
treating glioma has become one attractive approach. To
access the efficiency of DC vaccine, it is necessary to
monitor the distribution of DCs in the CNS or lymphoid
organs. Our goal is to target molecules, which are
involved in regulating DCs within the glioma context. In
this study we found that deficiency of ERK1 result in
tumor regression. 19F/1H MRI monitored the migration of
DCs and found that ERK1 can regulate DC migration.
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