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Abstract #0051

19F MRI for Evaluating ERK1 as a Factor Regulating Dendritic Cell Migration in High Grade Glioma

Min-Chi Ku 1 , Martin Gnther 1 , Conrad Martin 1 , Stefano Lepore 1 , Helmar Waiczies 1,2 , Andreas Pohlmann 1 , Susanne A. Wolf 3 , Helmut Kettenmann 3 , Thoralf Niendorf 1 , and Sonia Waiczies 1

1 Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrck Center for Molecular Medicine, Berlin, Germany, 2 MRI.TOOLS GmbH, Berlin, Berlin, Germany, 3 Cellular Neurosciences, Max Delbrck Center for Molecular Medicine, Berlin, Germany

Immunotherapy with dendritic cell based vaccines for treating glioma has become one attractive approach. To access the efficiency of DC vaccine, it is necessary to monitor the distribution of DCs in the CNS or lymphoid organs. Our goal is to target molecules, which are involved in regulating DCs within the glioma context. In this study we found that deficiency of ERK1 result in tumor regression. 19F/1H MRI monitored the migration of DCs and found that ERK1 can regulate DC migration.

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