Meeting Banner
Abstract #0045

Assessment of the Tumor Type-Specific Microenvironment Lactate, Vascularity, Hypoxia, Extracellular pH

Ellen Ackerstaff 1 , Natalia Kruchevsky 1 , Ekaterina Moroz 1 , Nirilanto Ramamonjisoa 1 , Rui V. Simoes 1 , H. Carl LeKaye 1 , Kristen L. Zakian 1 , Hansol Lee 2 , HyungJoon Cho 2 , Radka Stoyanova 3 , Inna Serganova 1 , Ronald G. Blasberg 1 , and Jason A. Koutcher 1

1 Memorial Sloan-Kettering Cancer Center, New York, NY, United States, 2 Ulsan National Institute of Science and Technology, Ulsan, Korea, 3 Miller School of Medicine, University of Miami, Miami, FL, United States

A hostile tumor microenvironment impacts tumor growth, progression, metastases, and treatment resistance. More aggressive tumors have been associated with increased lactate production, acidity, and suppressed T-cell immune response. Here, we characterize noninvasively in vivo the tumor microenvironment in tumor models of different origin and aggressivity and investigate the relationship of lactate metabolism, vascularity, hypoxia, and extracellular pH (pHe) to tumor type / aggressivity, using 1 H MRI/MRS/MRSI. Our data suggest that pHe does not directly relate to tumor lactate levels and that interplay of tumor metabolic activity and vascularization regulates tumoral pHe, showing the importance to assess these parameters independently.

This abstract and the presentation materials are available to members only; a login is required.

Join Here