Abstract #0041
In vivo characterization of inflammation by combined [ 11 C]-PBR28 PET imaging and 7 Tesla MRI in multiple sclerosis
Costanza Gianni' 1 , Audrey Fan 1 , Sindhuja Tirumalai Govindarajan 1 , Marco Loggia 1 , Nicole Zurcher Wimmer 1 , Ciprian Catana 1 , Jacob Hooker 1 , Emanuele Tinelli 2 , Celine Louapre 1 , Thomas A Anderson 3 , R.P. Kinkel 4 , and Caterina Mainero 1
1
Athinoula A. Martinos Center for
Biomedical Imaging, Massachusetts General
Hospital, Charlestown, MA, United States,
2
Neurology
and Psychiatry, Sapienza, University of Rome,
Rome, Italy,
3
Massachusetts
General Hospital, Boston, MA, United States,
4
Beth
Israel Deaconess Medical Center, Boston, MA,
United States
Inflammation through activation of macrophages
and microglia is a prominent feature in multiple
sclerosis. However, the relationship between
activated microglia / macrophages and structural
damage in the brain relies mainly on
neuropathological studies. Here, we combined
[11C]PBR28 imaging of activated microglia on a
high resolution, simultaneous human MR-PET
system with 7 Tesla in patients with secondary
progressive multiple sclerosis. We observed
diffuse microglia and macrophage activation
across the cortex and WM, which topographically
overlapped with visible lesions on 7 T T2*
images in some regions.
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