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Abstract #0041

In vivo characterization of inflammation by combined [ 11 C]-PBR28 PET imaging and 7 Tesla MRI in multiple sclerosis

Costanza Gianni' 1 , Audrey Fan 1 , Sindhuja Tirumalai Govindarajan 1 , Marco Loggia 1 , Nicole Zurcher Wimmer 1 , Ciprian Catana 1 , Jacob Hooker 1 , Emanuele Tinelli 2 , Celine Louapre 1 , Thomas A Anderson 3 , R.P. Kinkel 4 , and Caterina Mainero 1

1 Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2 Neurology and Psychiatry, Sapienza, University of Rome, Rome, Italy, 3 Massachusetts General Hospital, Boston, MA, United States, 4 Beth Israel Deaconess Medical Center, Boston, MA, United States

Inflammation through activation of macrophages and microglia is a prominent feature in multiple sclerosis. However, the relationship between activated microglia / macrophages and structural damage in the brain relies mainly on neuropathological studies. Here, we combined [11C]PBR28 imaging of activated microglia on a high resolution, simultaneous human MR-PET system with 7 Tesla in patients with secondary progressive multiple sclerosis. We observed diffuse microglia and macrophage activation across the cortex and WM, which topographically overlapped with visible lesions on 7 T T2* images in some regions.

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