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Abstract #0007

Increased Blood-Brain Barrier Leakage in Alzheimers Disease Detected with Dual Time-Resolution Dynamic Contrast Enhanced MRI

Harm J van de Haar 1 , Saartje Burgmans 1 , Matthias JP van Osch 2 , Jacobus FA Jansen 3 , Frank CG van Bussel 1 , Sau May Wong 1 , Martijn Wolters 3 , Ccile RLPN Jeukens 3 , Mark A van Buchem 2 , Paul AM Hofman 3 , Frans RJ Verhey 1 , and Walter H Backes 3

1 University of Maastricht, Maastricht, Netherlands, 2 Leiden University Medical Center, Leiden, Netherlands, 3 Maastricht University Medical Center, Maastricht, Netherlands

Blood-brain barrier defects prior to neuronal damage are a potential underlying mechanism for dementia. A dual-temporal resolution Dynamic Contrast Enhanced (DCE)-MRI protocol was used to detect differences in terms of fractional plasma volume (vp) and BBB leakage (Ki) in patients suffering from Alzheimers disease. The results suggest significantly stronger leakage in normal appearing white matter in the patients compared to the healthy controls, which supports our hypothesis that BBB leakage is increased in patients with (preclinical) Alzheimers dementia. Longitudinal research is necessary to reveal the exact relationship with Alzheimer pathology and small vessel disease.

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