Ying Wu1,
2, Huan Tan1, Ryan Hutten1, Tian Liu3,
Hongyan Du1, 4, Hector Ferral1, 2,
Matthew Walker1, 2, Joel Meyer1, 2,
Yi Wang3, Robert R. Edelman1, 5
1Department
of Radiology, NorthShore University HealthSystem, Evanston, IL, United
States; 2Department of Radiology, The University of Chicago
Pritzker School of Medicine, Chicago, IL, United States; 3Weill
Cornell Medical College, New York, United States; 4Center for
Clinical and Research Informatics (CCRI), NorthShore University HealthSystem,
Evanston, IL, United States; 5Department of Radiology,
Northwestern University Feinberg School of Medicine, Chicago, IL, United
States
Pathohistological and MR studies indicate possible iron accumulation in MS brain. Compared to previous iron susceptibility quantification methods, quantitative susceptibility mapping (QSM) is potentially more robust and more intrinsic to iron induced susceptibility. In this study, we performed QSM in MS patients to characterize lesion burden, and demonstrate the potential of QSM as a new sensitive clinical strategy for MS lesion identification, as well as a quantitative imaging marker for monitoring disease progression and/or responses to treatments. Conclusions: Our results provide preliminary evidence that the QSM holds promise for assessing iron change in MS brain and may add to clinical lesion visualization.